WiseOne wrote:
Incidentally...beware of what's being called "hypothyroidism" in the popular literature, which is a constellation of symptoms that could be diagnosed as lots of other things: (pre)menopause, chronic fatigue, etc. I don't think it's the same as the thyroid gland dysfunction due to autoimmune conditions, endocrine neoplasias etc that the lab tests are designed to pick up. I don't doubt that the recommended supplements could help with the symptoms and that it's likely that they're caused by some environmental or dietary factors, but that's not to say you know for certain that the cause is reduced thyroid function.
That's a good point. I think you're referring to "sub-clinical hypothyroidism" where you have some of the classic symptoms, but workups and imaging don't flag anything overtly abnormal (though the TSH range is rather wide being derived from an outlier, sickly population).
My Gma has a relatively recent neoplasma on her thyroid gland and so she had trouble regulating her body temperature and her T4 dose is now somewhat lower than normal at 86mcg. I do wonder if that neoplasma wasn't instigated by a chronically too high T4 replacement dose. She's been on T4 for at least 30 years, so that's pretty good for her PCP, even if he doesn't really know all the ins and outs of the whole hormone enchilada. He's definitely a treat the lab results rather than the patient type and its been challenging at times to get him to acknowledge reality even as she was burning up.
There's also the unacknowledged issue of a minority of women that don't respond to T4 alone and need T0, T1, T2, T3, T4 and calcitronin that are in natural thyroid extracts (I would not call those a supplement since regular thyroid glandular extracts have the active hormones removed). It is very challenging (to say the least) for mainstream PCP's and/or endocrinologists to grok. Maybe that's not the best way to fix an elevated rT3, but it certainly fits in with a drug for every ailment model. Interestingly, synthetic T4 in this mainstream context is actually bioidentical unlike the other pharmaceutical hormones. It must have been a fluke of how it was first discovered because I think Big Pharma was not funding the discovery, so no need to tweak it, make it toxic and patentable. Hence why T4 replacement is such a "widespread success". Doh!
Anyway, why do you think hypothyroidism (sub-clinical or overt) overwhelmingly strikes women rather than men?